CFRD Fact #14

April 7, 2008 at 7:15 am | In CFRD Facts, Cystic Fibrosis, Cystic Fibrosis Related Diabetes | Leave a Comment
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Complications of CFRD (poorly controlled):

Infections due to decreased white blood cell count phagocystosis.

  • Phagocystosis is the ability to encourage white blood cells to destroy bacteria.

Increased viscosity of mucus secretions with hyperglycemia and dehydration.

  • Dehydration is caused by the body trying to flush the excess blood glucose out in the urine.

Increased protein catabolism with CF and diabetes mellitus.

  • Protein catabolism is the breakdown of proteins into amino acids and simple derivative compounds, for transport into the cell.

Increased fatigue with poorly controlled diabetes mellitus.

CFRD Fact #12

March 28, 2008 at 7:01 am | In CFRD Facts, Cystic Fibrosis, Cystic Fibrosis Related Diabetes | Leave a Comment
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How might early diabetes cause CF clinical decline? It is currently unknown, but here are some theories:

  • Insulin Deficiency
    • Insulin is an anabolic hormone which promotes conservation of body protein, fat and carbohydrate stores.
  • Malnutrition and protein catabolism are clearly associated with death in CF.

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