CFRD Fact #14
April 7, 2008 at 7:15 am | In CFRD Facts, Cystic Fibrosis, Cystic Fibrosis Related Diabetes | Leave a CommentTags: complications, dehydration, phagocystosis, protein catabolism
Complications of CFRD (poorly controlled):
Infections due to decreased white blood cell count phagocystosis.
- Phagocystosis is the ability to encourage white blood cells to destroy bacteria.
Increased viscosity of mucus secretions with hyperglycemia and dehydration.
- Dehydration is caused by the body trying to flush the excess blood glucose out in the urine.
Increased protein catabolism with CF and diabetes mellitus.
- Protein catabolism is the breakdown of proteins into amino acids and simple derivative compounds, for transport into the cell.
Increased fatigue with poorly controlled diabetes mellitus.
CFRD Fact #12
March 28, 2008 at 7:01 am | In CFRD Facts, Cystic Fibrosis, Cystic Fibrosis Related Diabetes | Leave a CommentTags: insulin deficiency, malnutrition, protein catabolism
How might early diabetes cause CF clinical decline? It is currently unknown, but here are some theories:
- Insulin Deficiency
- Insulin is an anabolic hormone which promotes conservation of body protein, fat and carbohydrate stores.
- Malnutrition and protein catabolism are clearly associated with death in CF.
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